Drug intelligence / Profile preview

antibiotic + dexamethasone

Development stage
Unknown
Lead developer
Alcon
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Ophthalmic, Otic
01

Overview

This is a combination drug consisting of an antibiotic and dexamethasone (a corticosteroid). The specific antibiotics used in marketed products include tobramycin (Tobradex), ciprofloxacin (Ciprodex), or neomycin and polymyxin B (Maxitrol). These combinations are primarily used for the treatment of bacterial infections with associated inflammation—most commonly in the eye or ear. The antibiotic component acts by killing susceptible bacteria or inhibiting their growth; the dexamethasone component reduces inflammation by suppressing immune responses such as redness, swelling, and itching. This dual action helps both eradicate infection and control inflammatory symptoms[1][2][3][4][5].

Brand names
TobradexCiprodexMaxitrol
Other names
tobramycin/dexamethasoneciprofloxacin/dexamethasoneneomycin/polymyxin B/dexamethasone
02

Targets

GR (Glucocorticoid receptor)DNA gyraseTopo IV (Bacterial Topoisomerase IV)Bacterial Ribosome

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