antibiotic-University Magna Graecia-infective endocarditis (enterococcal)

The term **antibiotic-University Magna Graecia-infective endocarditis (enterococcal)** refers to the antibiotic treatment regimens evaluated in a Phase 4 clinical trial (NCT04866433) sponsored by the University Magna Graecia. This study is a randomized, open-label, non-inferiority trial designed to compare a shortened 4-week course of antibiotic therapy against the standard 6-week duration recommended by international guidelines for the treatment of enterococcal infective endocarditis. The regimens utilized in the trial include established antibiotics such as ampicillin, gentamicin, vancomycin, daptomycin, and linezolid, administered either as monotherapy or in combination. The primary objective of the research is to determine if a shorter treatment duration can achieve non-inferior clinical outcomes while reducing antibiotic pressure, healthcare costs, and the risk of adverse events or the selection of multidrug-resistant pathogens.

Other names

4-week duration of antibiotic therapy6-week duration of antibiotic therapy