antiscorpion venom serum + prazosin

**Antiscorpion venom serum + prazosin** is a combination therapy used primarily for the treatment of moderate to severe envenomation by the Indian red scorpion (*Mesobuthus tamulus*). The antiscorpion venom serum is a passive immunizing agent containing purified equine immunoglobulins capable of neutralizing circulating venom toxins when administered soon after the sting. Its mechanism of action involves the specific binding and neutralization of scorpion venom antigens, thereby ameliorating parasympathetic symptoms and reducing circulating active venom[2][1]. Prazosin is an alpha-1 adrenergic receptor antagonist that blocks the sympathetic and metabolic effects induced by scorpion venom, primarily counteracting hypertension and reducing preload and left ventricular impedance without increasing heart rate[1][3]. The combination is synergistic: antivenom acts principally on circulating venom (parasympathetic effects), while prazosin reverses the venom’s effects on the sympathetic nervous system (autonomic storm), leading to faster recovery and reduced morbidity and mortality[1]. The combination is standard of care in regions where *Mesobuthus tamulus* is endemic and is supported by randomized controlled trial evidence[1].

Brand names

Antiscorpion Venom Serum

Other names

AScVS plus PrazosinScorpion Antivenom plus Prazosin