antithrombin iii + sodium chloride

Normal saline + AT refers to a clinical formulation consisting of **antithrombin III (ATIII)** diluted in **0.9% sodium chloride (normal saline)**. Antithrombin III is a non-vitamin K-dependent protease inhibitor that inactivates thrombin and other activated coagulation factors (Factors IXa, Xa, XIa, and XIIa), thereby exerting a potent anticoagulant effect. In clinical practice, this combination is frequently utilized as a therapeutic intervention or a control arm in clinical trials investigating treatments for conditions characterized by coagulopathy, such as **sepsis-associated disseminated intravascular coagulation (DIC)**, hereditary antithrombin deficiency, and acute respiratory distress syndrome (ARDS). The saline serves as a vehicle for intravenous infusion, maintaining isotonicity and facilitating the systemic delivery of the antithrombin protein to restore physiological anticoagulant levels and mitigate microvascular thrombosis.

Other names

normal saline + ATnormal saline + antithrombin iiiantithrombin iii in 0.9% sodium chloride