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AO-176 + dexamethasone
- Development stage
- Unknown
- Lead developer
- Arch Oncology
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Oral
01
Overview
AO-176 is a next-generation humanized anti-CD47 monoclonal antibody developed to block the CD47/SIRPα interaction, thereby promoting tumor cell phagocytosis and direct tumor cell killing through programmed cell death. It binds preferentially to tumor cells over normal cells, minimizing off-target effects such as red blood cell binding. Dexamethasone is a synthetic glucocorticoid corticosteroid used for its anti-inflammatory and immunosuppressive properties in various conditions, including cancer. The combination of AO-176 with dexamethasone (and sometimes bortezomib) is being investigated in clinical trials for relapsed/refractory multiple myeloma[5][6][2].
- Other names
- dexamethasone
02
Targets
CD47 (Cluster of Differentiation 47)GR (Glucocorticoid receptor)
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