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apatinib + fluzoparib + adebrelimab

Development stage: Unknown
Lead developer: Hengrui Pharmaceutical
Modality: Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration: Oral, Intravenous

Overview

A combination therapy consisting of apatinib (a VEGFR2 inhibitor), fluzoparib (a PARP inhibitor), and adebrelimab (a PD-L1 inhibitor). This triple combination targets multiple cancer pathways simultaneously: angiogenesis inhibition through VEGFR2 blockade, DNA damage repair interference through PARP inhibition, and immune checkpoint blockade through PD-L1 inhibition.

Brand names: AiRuiYiAiTanAiRuiKa
Other names: Apatinib + Fluzoparib + AdebrelimabApatinib + Fluzoparib

Targets

VEGFR2 (Vascular endothelial growth factor receptor 2)CD274 (Programmed cell death protein 1 ligand 1)PARP2 (Poly (adp-ribose) polymerase 2)

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