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apatinib + sintilimab + SOX
- Development stage
- Unknown
- Lead developer
- Hengrui Pharmaceutical
- Modality
- Nucleic Acid-Directed Small Molecules → Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics, Covalent Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Apatinib + sintilimab + SOX is an investigational combination therapy for advanced gastric and gastroesophageal junction cancers, particularly in AFP-positive or HER2-negative subtypes. The regimen combines three agent types: - **Apatinib**: An oral small molecule inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2), which acts as an antiangiogenic targeted therapy. - **Sintilimab**: A monoclonal antibody targeting programmed cell death-1 (PD-1), functioning as an immune checkpoint inhibitor to enhance anti-tumor immune response. - **SOX regimen**: A standard chemotherapy protocol consisting of S-1 (an oral fluoropyrimidine derivative) and oxaliplatin (a platinum-based cytotoxic agent). This combination is being studied in phase II trials as a first-line or perioperative therapy for advanced gastric cancer, with evidence suggesting increased pathological response rates when compared to chemotherapy alone or chemotherapy plus PD-1 blockade. The synergy is based on simultaneous antiangiogenic, cytotoxic, and immune checkpoint inhibition mechanisms[1][3][4][6][7].
- Other names
- apatinib + sintilimab + S-1 + oxaliplatinNeoadjuvant apatinib combined with sintilimab and perioperative SOX
02
Targets
VEGFR2 (Vascular endothelial growth factor receptor 2)PDCD1 (Programmed cell death protein 1 receptor)DNATS (Thymidylate synthase)
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