Drug intelligence / Profile preview

APC (CD24-Ab-TG2-BP)

Development stage: Preclinical
Lead developer: Indiana University School of Medicine
Modality: Peptides, Antibody-Based Therapeutics

Overview

APC (CD24-Ab-TG2-BP) is a preclinical, first-in-class antibody-peptide conjugate being investigated for **high-grade serous ovarian cancer**. It couples a CD24-neutralizing antibody with a selective peptide inhibitor designed to block the interaction between tissue transglutaminase 2 and fibronectin. By concurrently inhibiting CD24 signaling and disrupting tissue transglutaminase 2-mediated tumor-cell interactions with the tumor microenvironment, APC is intended to suppress ovarian cancer stem-cell maintenance, spheroid formation, platinum-resistance biology, metastatic implantation, and tumor growth. In ovarian cancer xenograft models, APC reduced tumor volume, tumor weight, and metastatic burden versus IgG control.

Other names: CD24-Ab-TG2-BPCD-24-Ab-TG2-BPCD 24-Ab-TG2-BP

Targets

TGM2 (Tissue Transglutaminase 2)CD24 (Cluster of Differentiation 24)

Beyond the preview

Go deeper on APC (CD24-Ab-TG2-BP).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on APC (CD24-Ab-TG2-BP).

Explore the full profile