Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
APDC + mFOLFOX6
- Development stage
- Unknown
- Lead developer
- Naval Medical University
- Modality
- Dendritic Cell Vaccines → Immune Effector Cells → Other Cell Types → Cell Therapies, Small Molecules, Vaccines & Immunotherapeutics
- Administration
- Intravenous
01
Overview
APDC + mFOLFOX6 is a combination chemo-immunotherapy regimen being developed by the Second Military Medical University for the treatment of metastatic colorectal cancer. The regimen consists of an autologous tumor lysate-pulsed dendritic cell (APDC) vaccine and the modified FOLFOX6 (mFOLFOX6) chemotherapy regimen, which includes oxaliplatin, 5-fluorouracil, and leucovorin. The APDC vaccine is designed to stimulate a specific anti-tumor immune response by presenting autologous tumor antigens to the patient's T-cells. The mFOLFOX6 component provides direct cytotoxic effects by inhibiting DNA synthesis and inducing DNA damage, while potentially enhancing the immunogenicity of the tumor cells. This combination is currently being evaluated in Phase III clinical trials to determine its efficacy and safety compared to chemotherapy alone.
- Other names
- Antigen Pulsed Dendritic Cells + mFOLFOX6APDC + chemotherapyAPDC + Oxaliplatin + 5-Fluorouracil + Leucovorin
Beyond the preview
Go deeper on APDC + mFOLFOX6.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on APDC + mFOLFOX6.