aprepitant + dexamethasone

Aprepitant + dexamethasone is a combination regimen used primarily to prevent acute and delayed nausea and vomiting associated with highly emetogenic cancer chemotherapy. Aprepitant is a selective, high-affinity antagonist of the human substance P/neurokinin 1 (NK1) receptor, blocking signals in the brain that trigger nausea and vomiting. Dexamethasone is a synthetic glucocorticoid corticosteroid with anti-inflammatory and immunosuppressant properties, which also contributes to antiemetic efficacy. This combination is often used alongside other agents such as 5-HT3 receptor antagonists (e.g., ondansetron) for optimal control of chemotherapy-induced or postoperative nausea and vomiting[1][3][4][5][6].

Brand names

Emend

Other names

aprepitant and dexamethasonedexamethasone and aprepitantDA regimen