aprepitant + ondansetron

Aprepitant + ondansetron is a fixed-dose combination of two antiemetic agents used together to prevent and treat nausea and vomiting, particularly those induced by cancer chemotherapy, radiation therapy, or surgery. Aprepitant is a selective high-affinity antagonist of the human substance P/neurokinin 1 (NK1) receptor, blocking the action of substance P in the central nervous system to prevent both acute and delayed emesis. Ondansetron is a selective serotonin 5-HT3 receptor antagonist that blocks serotonin both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone. The combination has demonstrated superior efficacy compared to monotherapy with either agent for preventing radiation-induced or chemotherapy-induced nausea and vomiting[4][6][8].