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ARC1779 + desmopressin
- Development stage
- Phase 2
- Lead developer
- Baxter
- Modality
- RNA Aptamers → RNA Therapeutics → Nucleic Acid Therapeutics, DNA Aptamers → DNA Therapeutics → Nucleic Acid Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
**ARC1779 + desmopressin** is a combination of two drugs used in clinical research to investigate platelet function disorders, particularly type 2B von Willebrand disease. ARC1779 is a nucleotide aptamer that binds and inhibits the A1 domain of von Willebrand Factor (VWF), blocking its interaction with the platelet glycoprotein Ib (GPIb) receptor. Desmopressin is a synthetic analogue of vasopressin that increases release of large VWF multimers but, in type 2B VWD, can induce thrombocytopenia due to excessive platelet aggregation. The combination is intended to prevent desmopressin-induced thrombocytopenia by inhibiting excessive VWF-mediated platelet binding while simultaneously increasing VWF levels[1][2][3].
- Other names
- ARC1779 + desmopressin
02
Targets
AVPR2 (Arginine vasopressin V2 receptor)BB-031 (Von Willebrand factor)
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