Drug intelligence / Profile preview

argatroban + aspirin + gammaglobulin + prednisolone

Development stage
Preclinical
Lead developer
Daiichi Sankyo
Modality
Small Molecules
Administration
Intravenous, Oral
01

Overview

This is a combination therapy consisting of argatroban (a direct thrombin inhibitor), aspirin (an antiplatelet agent), intravenous immunoglobulin (gammaglobulin), and prednisolone (a corticosteroid). While argatroban and aspirin combinations have been studied for prevention of coronary thrombosis and treatment of acute ischemic stroke, the specific four-drug combination including gammaglobulin and prednisolone is not well-documented in the literature. Argatroban is a synthetic direct thrombin inhibitor used for prevention and treatment of thrombosis, particularly in patients with heparin-induced thrombocytopenia (HIT). Aspirin functions as an antiplatelet agent through inhibition of thromboxane synthesis. The combination of argatroban and aspirin has shown potential efficacy in preventing coronary thrombosis and treating certain types of stroke.

02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)F2 (Thrombin)GR (Glucocorticoid receptor)PGHS-1 (Prostaglandin G/H Synthase 1)

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