Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
argon + oxygen
- Development stage
- Unknown
- Lead developer
- Negovsky Research Institute of Reanimatology
- Modality
- Small Molecules
- Administration
- Inhalation
01
Overview
Argon + oxygen is a medicinal gas mixture being investigated for its neuroprotective properties during high-risk vascular surgeries. Developed by the Negovsky Reanimatology Research Institute, this combination is specifically being evaluated in the PAIRS trial for patients undergoing carotid endarterectomy (CEA) to prevent perioperative ischemic brain injury and postoperative cognitive decline. Argon, an inert gas, exerts its effects through multiple pathways, including the regulation of TLR2/4, ERK1/2, Nrf2, and NF-κB signaling. It has been shown to inhibit the NLRP3 inflammasome and suppress microglial activation, thereby reducing neuroinflammation and secondary neuronal damage. Unlike xenon, argon is cost-effective and technologically simpler to administer via inhalation.
- Other names
- Argon-oxygen breathing mixtureArgon-oxygen gas mixture
02
Targets
NF-κBTLR2 (Toll-like Receptor 2)MAPK3 (Mitogen-activated protein kinase 1)TLR4 (Toll-like receptor 4)
Beyond the preview
Go deeper on argon + oxygen.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on argon + oxygen.