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Drug intelligence / Profile preview
aripiprazole + fluoxetine + bupropion + sertraline + lamotrigine
- Development stage
- Preclinical
- Lead developer
- Otsuka Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This is a combination of five psychiatric medications often used in treatment-resistant depression or complex psychiatric disorders. It includes aripiprazole (an atypical antipsychotic), fluoxetine and sertraline (both SSRIs), bupropion (an NDRI), and lamotrigine (an anticonvulsant/mood stabilizer). Each medication has distinct mechanisms of action and potential interactions with the others.
02
Targets
DRD2 (Dopamine D2 Receptor)DAT (Dopamine plasma membrane transport protein)Nicotinic Acetylcholine ReceptorNET (Norepinephrine Transporter)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))HTR2A (Serotonin receptor 5-HT2A)SERT (Sodium-dependent serotonin transporter)NaV (Voltage-gated sodium channels)
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