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aripiprazole + perphenazine
- Development stage
- Preclinical
- Lead developer
- Taiho Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral, Intramuscular
01
Overview
A combination of two antipsychotic medications with different mechanisms of action. Aripiprazole is an atypical (second-generation) antipsychotic that acts as a partial agonist at dopamine D2 receptors and serotonin 5-HT1A receptors, while functioning as an antagonist at serotonin 5-HT2A receptors. Perphenazine is a typical (first-generation) antipsychotic from the phenothiazine class that primarily works as a dopamine D1 and D2 receptor antagonist. It also binds to alpha adrenergic receptors and calmodulin. This combination has been studied for treatment-resistant schizophrenia.
02
Targets
HTR2A (Serotonin receptor 5-HT2A)CaM (Calmodulin)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))DRD1 (Dopamine D1 Receptor)ADRA1A (α1A)DRD2 (Dopamine D2 Receptor)
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