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aripiprazole + sertraline
- Development stage
- Phase 1
- Lead developer
- Taiho Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A combination formulation of aripiprazole (an atypical antipsychotic) and sertraline (a selective serotonin reuptake inhibitor) developed for the treatment of major depressive disorder and bipolar depression. It combines serotonin reuptake inhibition from sertraline with modulation of dopamine and serotonin receptors from aripiprazole.
- Other names
- ASC-01ASC01ASC 01aripiprazole/sertraline combination drugsertraline/aripiprazole
02
Targets
SERT (Sodium-dependent serotonin transporter)ABCB1 (P-glycoprotein)HTR2A (Serotonin receptor 5-HT2A)SIGMAR1 (Sigma non-opioid intracellular receptor 1)ADRA1A (α1A)DAT (Dopamine plasma membrane transport protein)DRD2 (Dopamine D2 Receptor)NET (Norepinephrine Transporter)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))
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