Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
arsenic trioxide + fluorouracil + leucovorin
- Development stage
- Unknown
- Lead developer
- University of Miami Miller School of Medicine
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
This is a combination chemotherapy regimen consisting of arsenic trioxide (ATO), fluorouracil (5-FU), and leucovorin (LV). Arsenic trioxide is known for its ability to downregulate thymidylate synthase (TS), thereby resensitizing tumor cells that have become resistant to 5-fluorouracil. Fluorouracil is an antimetabolite that inhibits DNA synthesis by targeting TS, while leucovorin enhances the binding of 5-FU to TS, increasing its cytotoxicity. This combination has been investigated primarily in patients with relapsed or refractory metastatic colorectal cancer who have failed prior therapies. The regimen aims to improve the efficacy of standard fluoropyrimidine-based chemotherapy by overcoming resistance mechanisms through TS modulation[1][2][6].
- Other names
- arsenic trioxide5-fluorouracilleucovorinATO + 5-FU + LV
02
Targets
TS (Thymidylate synthase)
Beyond the preview
Go deeper on arsenic trioxide + fluorouracil + leucovorin.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on arsenic trioxide + fluorouracil + leucovorin.