Drug intelligence / Profile preview

artemisia annua extract + rice grain extract

Development stage
Preclinical
Lead developer
Novartis
Modality
Small Molecules, Implantable Devices → Device-based Delivery → Drug Delivery Systems, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Inhalation Devices → Device-based Delivery → Drug Delivery Systems
Administration
Oral, Topical
01

Overview

Artemisia annua extract + rice grain extract is a combination product consisting of two plant-derived ingredients. Artemisia annua, also known as sweet wormwood, is a medicinal plant whose primary active compound, artemisinin, has been widely used for its potent antimalarial properties. Artemisinin and its derivatives are the basis for artemisinin-based combination therapies (ACTs), which are the most effective treatments currently available for drug-resistant malaria[1][2][4]. In addition to antimalarial activity, extracts from Artemisia annua may have other traditional uses and potential anti-inflammatory or antiparasitic effects[4]. Rice grain extract is less well characterized in pharmaceutical contexts but may be included as a carrier or to provide additional nutritional or functional benefits. The specific mechanism of action for this combination depends primarily on the presence of artemisinin from Artemisia annua, which acts rapidly against malaria parasites by generating reactive oxygen species that damage parasite proteins and membranes[1][2]. The role of rice grain extract in this combination is not clearly defined in current scientific literature.

02

Targets

PfDdi1 (DNA damage-inducible protein 1 protease)PfPI3K (Plasmodium falciparum phosphatidylinositol 3-kinase)

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