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artesunate + ganciclovir
- Development stage
- Phase 2
- Lead developer
- Amivas
- Modality
- Small Molecules
- Administration
- Intravenous, Oral
01
Overview
Artesunate + ganciclovir is a combination regimen of two drugs: **artesunate**, an antimalarial agent with antiviral properties, and **ganciclovir**, a nucleoside analogue antiviral. This combination is under investigation for the treatment of **cytomegalovirus (CMV) infections**, primarily in immunocompromised patients such as solid organ transplant recipients. Artesunate inhibits viral replication by interfering with viral proteins and has demonstrated **in vitro synergism** with ganciclovir, potentially enhancing antiviral activity and reducing drug resistance[2][3][1][5]. Ganciclovir targets the **viral DNA polymerase**, interfering with viral DNA synthesis and replication. Combined, these drugs act on different viral mechanisms, and are being evaluated as an alternative or adjunct to monotherapy to improve efficacy for CMV and limit toxicity[1][2][3][5].
- Other names
- artesunate + ganciclovir
02
Targets
CMV DNA polymerase (Human cytomegalovirus DNA polymerase)
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