Drug intelligence / Profile preview

artesunate + mefloquine

Development stage
Phase 4
Lead developer
Drugs for Neglected Diseases initiative
Modality
Small Molecules
Administration
Oral
01

Overview

**Artesunate + mefloquine** is an oral fixed-dose artemisinin-based combination therapy for acute uncomplicated *Plasmodium falciparum* malaria, including some mixed *Plasmodium* infections. It combines artesunate, a rapidly acting artemisinin derivative, with the longer-acting quinoline antimalarial mefloquine to clear residual blood-stage parasites after the initial rapid parasite reduction. The ASMQ fixed-dose product was developed to simplify three-day treatment, support adherence, and reduce the risk of functional monotherapy. Fixed-dose ASMQ products have been developed and registered or supplied in multiple endemic settings, including paediatric tablet and granule formulations. ([dndi.org](https://dndi.org/research-development/portfolio/asmq))

Brand names
ArtequinArtequin PaediatricFalcigo PlusFalcigo Plus JuniorFarmanguinhos Artesunato + Mefloquina
Other names
AS-MQASMQMAMAS3MAS-3MAS 3MQ-ASMQASartesunate-mefloquineartesunate/mefloquinemefloquine + artesunatemefloquine-artesunate
02

Targets

PfHRP2 (Plasmodium falciparum histidine-rich protein II)PfACBP (Plasmodium falciparum acyl-CoA-binding protein)

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