AS-101 + zidovudine

AS-101 + zidovudine is a combination of two small molecules: - **AS-101** is an organotellurium compound with immunomodulatory, anti-inflammatory, antiviral, and antimicrobial activity. It has been explored in the treatment of autoimmune diseases, inflammatory conditions, and for its antimicrobial effect against drug-resistant bacteria such as carbapenem-resistant Klebsiella pneumoniae (CRKP). - **Zidovudine** (also known as azidothymidine, AZT, or ZDV) is a nucleoside reverse transcriptase inhibitor (NRTI) primarily used for the treatment of HIV infection, but it also exhibits some broad-spectrum antiviral and antimicrobial effects. Recent research demonstrates that the combination of AS-101 and zidovudine exhibits strong *synergistic* antimicrobial activity against CRKP, reducing the minimum inhibitory concentrations (MICs) of both drugs, suggesting improved efficacy at lower doses. This combination targets difficult-to-treat bacterial infections, especially those resistant to carbapenems[1].

Other names

AS101 + AZT