Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
ascorbic acid + alpha-tocopherol + selenium
- Development stage
- Phase 3
- Lead developer
- National Cancer Institute
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This combination drug consists of ascorbic acid (Vitamin C), alpha-tocopherol (Vitamin E), and selenium. It was evaluated by the National Cancer Institute (NCI) in the Shandong Intervention Trial, a large-scale Phase 3 study in Linqu County, China. The intervention aimed to inhibit the progression of precancerous gastric lesions—such as chronic atrophic gastritis, intestinal metaplasia, and dysplasia—to gastric cancer in a high-risk population. Ascorbic acid and alpha-tocopherol act as antioxidants, while selenium is a trace element with potential chemopreventive properties. Long-term follow-up data indicated that this supplementation significantly reduced gastric cancer incidence and mortality over a 22-year period.
- Other names
- vitamin supplementShandong Intervention Trial vitamin supplementvitamin C + vitamin E + selenium
02
Targets
GPX1 (Glutathione peroxidase 1)TXNRD2 (Thioredoxin reductase 2)GPX4 (Glutathione peroxidase 4)
Beyond the preview
Go deeper on ascorbic acid + alpha-tocopherol + selenium.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on ascorbic acid + alpha-tocopherol + selenium.