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ascorbic acid + bevacizumab
- Development stage
- Unknown
- Lead developer
- University of Nebraska Medical Center
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
This investigational combination therapy, studied by the University of Nebraska, pairs high-dose intravenous ascorbic acid (Vitamin C) with bevacizumab for the treatment of recurrent high-grade gliomas, including glioblastoma. Bevacizumab is a monoclonal antibody that inhibits angiogenesis by targeting vascular endothelial growth factor (VEGF). High-dose ascorbic acid is hypothesized to exert anti-cancer effects by acting as a pro-oxidant, generating hydrogen peroxide that leads to oxidative DNA damage in tumor cells. The Phase I study aims to determine the safety and optimal dosing of this combination in patients whose tumors have recurred after standard treatments.
- Brand names
- Avastin
- Other names
- Vitamin CL-ascorbic acid
02
Targets
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