ASP8062 + alcohol

ASP8062 + alcohol is an experimental combination of **ASP8062**, a novel orally active small molecule that acts as a **positive allosteric modulator of the gamma-aminobutyric acid type B (GABA-B) receptor**, administered with **alcohol (ethanol)**. ASP8062 is under investigation for the treatment of **alcohol use disorder (AUD)** and **opioid use disorder (OUD)**. It is designed to modulate inhibitory neurotransmission by enhancing GABA-B receptor activity, a mechanism thought to reduce substance use behaviors. Combination studies specifically assess whether ASP8062 alters the pharmacokinetics, pharmacodynamics, safety, cognitive effects, or tolerability of alcohol, with clinical data showing that ASP8062 combined with alcohol can potentiate mild cognitive impairment versus alcohol alone, though ASP8062 does not further augment most alcohol-related adverse effects and is generally well tolerated when co-administered[2][4][5].