aspirin + clopidogrel

aspirin + clopidogrel is a combination antiplatelet regimen utilized as the standard medical therapy arm in clinical trials for stroke prevention, specifically in patients with symptomatic intracranial arterial stenosis. This regimen typically involves dual antiplatelet therapy (DAPT) with aspirin, an irreversible inhibitor of prostaglandin G/H synthase 1 (COX-1), and clopidogrel, a thienopyridine-class P2Y12 receptor antagonist. By inhibiting both the thromboxane A2 and adenosine diphosphate (ADP) pathways of platelet activation, the combination provides synergistic antithrombotic effects. In the context of the study by Can Tho Stroke International Services Hospital, the treatment protocol consists of 90 days of DAPT (aspirin 100 mg and clopidogrel 75 mg) followed by clopidogrel monotherapy to prevent recurrent ischemic events in the territory of the symptomatic intracranial artery.

Brand names

DuoPlavinCo-Plavix

Other names

Medical treatment aloneMedical Treatment Alone-Can Tho Stroke International Services Hospital-ischemic stroke-intracranial arterial stenosisDual antiplatelet therapyDAPT