aspirin + clopidogrel + statins

Aspirin + clopidogrel + statins is a therapeutic combination regimen frequently referred to as optimal medical therapy (OMT) for the secondary prevention of cardiovascular events in patients with coronary heart disease (CHD). This regimen combines two antiplatelet agents with a lipid-lowering agent. **Aspirin** irreversibly inhibits cyclooxygenase-1 (COX-1), thereby preventing the synthesis of thromboxane A2 and inhibiting platelet aggregation. **Clopidogrel** is a thienopyridine that acts as a selective and irreversible antagonist of the P2Y12 ADP receptor on platelets, providing a complementary mechanism for preventing thrombus formation. **Statins** (HMG-CoA reductase inhibitors) lower LDL cholesterol by inhibiting the rate-limiting enzyme in cholesterol biosynthesis and offer pleiotropic benefits such as plaque stabilization and anti-inflammatory effects. In the context of clinical research at The First Affiliated Hospital with Nanjing Medical University, this combination serves as the standard pharmacological baseline for evaluating the efficacy of individualized exercise training based on cardiopulmonary exercise testing (CPET) in elderly patients with CHD.

Other names

optimal medical therapyOMT