Drug intelligence / Profile preview

aspirin + dipyridamole

Development stage
Unknown
Lead developer
Boehringer Ingelheim
Modality
Small Molecules
Administration
Oral
01

Overview

aspirin + dipyridamole is an oral combination antiplatelet therapy developed and manufactured by Hubei Biocause Pharmaceutical. It consists of two active ingredients with complementary mechanisms: aspirin and dipyridamole. Aspirin acts by irreversibly inhibiting cyclooxygenase-1 (COX-1), which prevents the formation of thromboxane A2, a key mediator in platelet aggregation. Dipyridamole inhibits the activity of phosphodiesterase (PDE), leading to increased intracellular levels of cAMP and cGMP, and also blocks the uptake of adenosine into platelets and other cells, further enhancing its antiplatelet effects. This combination is approved for the secondary prevention of ischemic stroke and transient ischemic attacks (TIA).

Brand names
Jinbaotong金保通
Other names
阿司匹林双嘧达莫片Aspirin/dipyridamoleDipyridamole/aspirin
02

Targets

PDE (Phosphodiesterase family)ENT1 (Solute carrier family 29 member 1)PGHS-1 (Prostaglandin G/H Synthase 1)

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