Drug intelligence / Profile preview

Aspirin + Lovaza

Development stage
Unknown
Lead developer
GSK
Modality
Small Molecules
Administration
Oral
01

Overview

Aspirin + Lovaza is a combination of two agents: aspirin, an antiplatelet and anti-inflammatory drug, and Lovaza, a prescription formulation of highly purified omega-3-acid ethyl esters (primarily eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]). Aspirin irreversibly inhibits cyclooxygenase enzymes (COX1/COX2), reducing thromboxane A2 production to inhibit platelet aggregation. Lovaza acts by reducing hepatic production of triglycerides through inhibition of esterification processes in the liver. It is indicated as an adjunct to diet for adults with severe hypertriglyceridemia (≥500 mg/dL). The combination may have additive effects on platelet function and lipid metabolism but also increases bleeding risk due to overlapping effects on coagulation[4][5][6].

Other names
omega-3-acid ethyl estersomega3-acid ethyl estersomega 3-acid ethyl estersomega-3 polyunsaturated fatty acidsomega3 polyunsaturated fatty acidsomega 3 polyunsaturated fatty acidsEPA and DHA (for Lovaza)
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)

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