aspirin + omeprazole

Aspirin + omeprazole is a fixed-dose combination drug containing two active ingredients: aspirin, an antiplatelet agent (salicylate), and omeprazole, a proton pump inhibitor (PPI). It is indicated for patients who require long-term low-dose aspirin therapy to reduce the risk of secondary cardiovascular or cerebrovascular events (such as heart attack or stroke) but are at increased risk of developing gastric ulcers due to chronic aspirin use. Aspirin works by irreversibly inhibiting cyclooxygenase-1 (COX-1), thereby preventing platelet aggregation and reducing thrombotic events. Omeprazole decreases gastric acid secretion by irreversibly inhibiting the H+/K+ ATPase enzyme system in gastric parietal cells, thus lowering the risk of gastrointestinal ulceration associated with chronic NSAID use. The combination is formulated as a coordinated delivery system—immediate-release omeprazole with enteric-coated aspirin—to optimize GI protection while maintaining antiplatelet efficacy[1][2][3][4][7].

Brand names

Yosprala

Other names

aspirin and omeprazoleaspirin/omeprazoleASA/omeprazole