Drug intelligence / Profile preview

aspirin + rosuvastatin

Development stage
Unknown
Lead developer
Bayer
Modality
Small Molecules
Administration
Oral
01

Overview

Aspirin + rosuvastatin is a fixed-dose combination of two pharmaceutical agents used primarily for the prevention of cardiovascular events such as heart attack and stroke. Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) with antiplatelet properties, acting by irreversibly inhibiting cyclooxygenase 1 (COX1), thereby reducing thromboxane A2 production and preventing platelet aggregation. Rosuvastatin is an HMG-CoA reductase inhibitor (statin) that lowers cholesterol by inhibiting the enzyme responsible for cholesterol synthesis in the liver, leading to reduced low-density lipoprotein (LDL) cholesterol and increased high-density lipoprotein (HDL) cholesterol. The combination targets both lipid lowering and antithrombotic pathways to reduce the risk of atherosclerotic cardiovascular disease[1][2][5][6].

Brand names
DanavishRozucor ASPRozavel ARoseday-AJupiros-AConsivas-AspRazel-AArvast-ARosumac ASPRosukem-ARozustat-AS
Other names
rosuvastatin + aspirin
02

Targets

PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)

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