Drug intelligence / Profile preview

astragalus + panax notoginseng + borneol

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

This is a combination of three traditional Chinese medicine (TCM) ingredients—Astragalus (commonly Astragalus membranaceus), Panax notoginseng, and Borneol. Astragalus and Panax notoginseng are widely used in TCM for their anti-inflammatory, immunomodulatory, neuroprotective, and cardiovascular effects. The main active components are astragaloside IV from Astragalus and saponins from Panax notoginseng. Borneol is a terpene that acts as a penetration enhancer to facilitate the delivery of other compounds across the blood-brain barrier. Preclinical studies show that this combination can reduce cerebral ischemia-reperfusion injury by promoting neurogenesis, regulating microglial polarization toward an anti-inflammatory phenotype (M2), inhibiting pro-inflammatory pathways such as TLR4/MyD88/NFκB signaling, reducing infarct volume in stroke models, and improving neurological function. The addition of borneol enhances the brain penetration of active components from Astragalus and Panax notoginseng[1][2]. This combination has also been studied for potential benefits in chronic kidney disease when combined with other herbs[3][5][6].

Other names
astragalus membranaceus + panax notoginseng + borneolhuangqi + sanqi + borneol
02

Targets

TLR4 (Toll-like receptor 4)MYD88 (Myeloid differentiation primary response protein MyD88)NF-κB

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