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astragalus membranaceus + budesonide + terbutaline

Development stage
Preclinical
Lead developer
Fujian Medical University Union Hospital
Modality
Small Molecules
Administration
Inhalation, Oral, Intranasal
01

Overview

This is a non-standard, multi-ingredient combination consisting of Astragalus membranaceus (a traditional herbal medicine), budesonide (a synthetic inhaled corticosteroid), and terbutaline (a short-acting beta-2 adrenergic agonist bronchodilator). - **Astragalus membranaceus** is an adaptogenic herb used in traditional Chinese medicine for its purported immunomodulatory, anti-inflammatory, antioxidant, and anti-aging effects. It is commonly promoted as a dietary supplement for immune support and respiratory health but lacks robust clinical evidence for most indications[1][3][5]. - **Budesonide** is an inhaled corticosteroid that reduces airway inflammation by binding to the glucocorticoid receptor, suppressing pro-inflammatory gene expression. It is widely used in asthma and chronic obstructive pulmonary disease (COPD) management[6][8]. - **Terbutaline** is a selective beta-2 adrenergic receptor agonist that acts as a bronchodilator by relaxing bronchial smooth muscle. It provides rapid relief from bronchospasm in conditions like asthma[6][8]. There are no known approved pharmaceutical products or fixed-dose combinations containing all three ingredients together; this combination would be considered experimental or investigational if used clinically.

02

Targets

GR (Glucocorticoid receptor)ADRB2 (β2)

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