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atazanavir + ritonavir + tenofovir disoproxil fumarate + emtricitabine
- Development stage
- Unknown
- Lead developer
- Bristol Myers Squibb
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This is a combination antiretroviral therapy regimen used for the treatment of HIV-1 infection. It combines four medications: atazanavir (a protease inhibitor), ritonavir (a pharmacokinetic enhancer/booster), and the nucleoside/nucleotide reverse transcriptase inhibitors tenofovir disoproxil fumarate and emtricitabine. Atazanavir is boosted with low-dose ritonavir to optimize its pharmacokinetic parameters and efficacy. This combination has shown potent antiviral activity with once-daily dosing, making it suitable for initial HIV treatment or as part of a treatment regimen for HIV-infected individuals.
- Brand names
- Truvada
- Other names
- ATV/r + FTC/TDFatazanavir/ritonavir + emtricitabine/tenofovir disoproxil fumarate
02
Targets
Human immunodeficiency virus type 1 reverse transcriptaseCYP3A4 (Cytochrome P450 3A4)PR (Progesterone receptor)
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