atenolol + chlorthalidone

**Atenolol + chlorthalidone** is an oral combination medication used primarily to treat high blood pressure (hypertension)[1][2][3][4][5][6][7]. It consists of two active components: - **Atenolol:** a cardioselective beta-1 adrenergic receptor blocker that decreases heart rate and cardiac workload by blocking catecholamine action on beta-1 receptors in the heart[1][2][4][5]. - **Chlorthalidone:** a thiazide-like diuretic that acts on the kidneys to increase sodium and water excretion, lowering blood pressure by reducing plasma volume[1][2][4][5]. The combination's antihypertensive effects are additive, with no mutual interference in bioavailability[2]. It is usually reserved for patients already stabilized on the individual agents and not recommended as initial therapy[1]. Atenolol + chlorthalidone is available as tablets in various strengths, such as 50 mg/25 mg and 100 mg/25 mg[2][5]. Common side effects include gastrointestinal upset, dizziness, gout, and electrolyte disturbances. Serious adverse reactions may include liver dysfunction, pancreatitis, severe bradycardia, and psychosis[1][2][5].

Brand names

Tenoretic

Other names

co-tenidone