Drug intelligence / Profile preview

atezolizumab + bevacizumab + cobimetinib

Development stage
Phase 2
Lead developer
Roche
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration
Oral, Intravenous
01

Overview

A combination therapy consisting of atezolizumab (a PD-L1 inhibitor), bevacizumab (an anti-angiogenic agent), and cobimetinib (a MEK inhibitor). This regimen targets multiple aspects of cancer biology simultaneously through immune checkpoint inhibition, angiogenesis inhibition, and MAPK pathway inhibition.

02

Targets

MEK1 (Dual specificity mitogen-activated protein kinase kinase 1)CD274 (Programmed cell death protein 1 ligand 1)VEGFA (Vascular endothelial growth factor A)

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