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atezolizumab + carboplatin

Development stage: Unknown
Lead developer: Roche
Modality: DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics
Administration: Intravenous

Overview

Atezolizumab is a monoclonal antibody that acts as an immune checkpoint inhibitor by targeting PD-L1, enhancing the body's immune response against cancer cells. Carboplatin is a platinum-based chemotherapy drug that interferes with DNA replication, leading to cell death. This combination is used to treat various cancers, including metastatic triple-negative breast cancer and small-cell lung cancer, by synergistically improving progression-free and overall survival.

Targets

DNACD274 (Programmed cell death protein 1 ligand 1)

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