Drug intelligence / Profile preview

atezolizumab + carboplatin + paclitaxel + pertuzumab + trastuzumab

Development stage
Phase 3
Lead developer
Genentech
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration
Intravenous
01

Overview

This is a combination therapy regimen that includes multiple anti-cancer agents with different mechanisms of action. The combination includes: 1. Atezolizumab - a PD-L1 inhibitor immunotherapy 2. Carboplatin - a platinum-based chemotherapy agent 3. Paclitaxel - a taxane chemotherapy agent 4. Pertuzumab - a HER2-targeted monoclonal antibody that prevents HER2/HER3 dimerization 5. Trastuzumab - a HER2-targeted monoclonal antibody This combination therapy leverages both chemotherapy (carboplatin and paclitaxel) and targeted therapy (pertuzumab and trastuzumab) components along with immunotherapy (atezolizumab) to treat HER2-positive cancers. The dual HER2 blockade with pertuzumab and trastuzumab has shown synergistic effects in clinical studies.

02

Targets

DNAERBB2 (Erb-b2 receptor tyrosine kinase 2)ERBB3 (Erb-b2 receptor tyrosine kinase 3)MicrotubuleCD274 (Programmed cell death protein 1 ligand 1)TUBB (Tubulin (alpha and beta subunits))

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