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atorvastatin + amlodipine + losartan + hydrochlorothiazide
- Development stage
- Preclinical
- Lead developer
- Pfizer
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A combination medication containing four active ingredients used to treat hypertension and cardiovascular disease. Atorvastatin is a statin that lowers cholesterol levels by inhibiting HMG-CoA reductase. Amlodipine is a calcium channel blocker that relaxes blood vessels and increases blood supply to the heart. Losartan is an angiotensin II receptor blocker that blocks substances causing blood vessel constriction. Hydrochlorothiazide is a thiazide diuretic that reduces water retention by increasing urine flow.
- Other names
- SCCS PolypillVanderbilt Polypill
02
Targets
HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)AGTR1 (Angiotensin II Type-1 receptor)SLC12A3 (Thiazide-sensitive sodium-chloride cotransporter)
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