atorvastatin + fluvastatin + lovastatin + pravastatin + rosuvastatin + simvastatin

This is a combination of six statins—atorvastatin, fluvastatin, lovastatin, pravastatin, rosuvastatin, and simvastatin. Statins are a class of lipid-lowering medications that act as competitive inhibitors of the enzyme HMG-CoA reductase. This enzyme catalyzes the rate-limiting step in cholesterol biosynthesis via the mevalonate pathway. By inhibiting HMG-CoA reductase, these drugs reduce hepatic cholesterol synthesis and increase LDL receptor expression on hepatocytes, leading to enhanced clearance of low-density lipoprotein cholesterol (LDL-C) from the bloodstream. The result is a significant reduction in circulating LDL-C levels and overall cardiovascular risk[6][9]. Each statin has unique pharmacokinetic properties but shares this core mechanism.