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atorvastatin + guided physical exercise
- Development stage
- Unknown
- Lead developer
- Tampere University Hospital
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This intervention combines the HMG-CoA reductase inhibitor atorvastatin with a supervised, guided physical exercise program (including aerobic and resistance training) to treat metastatic cancers. Investigated by Tampere University Hospital in the Phase 3 MOVES trial, the combination aims to modify the cancer microenvironment and metabolism to enhance the effectiveness of standard oncological treatments. Atorvastatin, a small molecule statin, inhibits cholesterol biosynthesis, while the exercise component is designed to improve patient outcomes and potentially synergistic therapeutic responses in metastatic breast, kidney, ovarian, and prostate cancers.
- Brand names
- Lipitor
- Other names
- MOVES trial intervention
02
Targets
HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)
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