atorvastatin + perindopril

Atorvastatin + perindopril is a fixed-dose combination of two small molecule drugs used primarily for the management of patients with both hypertension and dyslipidemia, as well as for cardiovascular risk reduction. Atorvastatin is an HMG-CoA reductase inhibitor (statin) that lowers cholesterol by inhibiting the enzyme responsible for cholesterol synthesis in the liver, thereby reducing low-density lipoprotein cholesterol (LDL-C), total cholesterol, and triglycerides while increasing high-density lipoprotein cholesterol (HDL-C)[2]. Perindopril is an angiotensin-converting enzyme (ACE) inhibitor that lowers blood pressure by preventing the conversion of angiotensin I to angiotensin II, leading to vasodilation and reduced aldosterone secretion[6][8]. The combination targets both lipid abnormalities and elevated blood pressure, providing synergistic cardiovascular protection in patients at risk or with established coronary artery disease[5]. This dual therapy may be particularly beneficial in secondary prevention settings.

Brand names

Euvascor

Other names

atorvastatin/perindopril arginine fixed-dose combination