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autologous bone marrow-derived mesenchymal stem cells (Hospital Clínico San Carlos)
- Development stage
- Unknown
- Lead developer
- Fundación para la Investigación Biomédica del Hospital Clínico San Carlos
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Implant
01
Overview
This investigational therapy consists of autologous bone marrow-derived mesenchymal stem cells (MSCs) developed by researchers at Hospital Clínico San Carlos in Madrid for the treatment of full-thickness rotator cuff tears. The treatment protocol involves harvesting MSCs from the patient's bone marrow, expanding them in vitro, and then surgically implanting approximately 20 million cells seeded onto a collagen membrane scaffold (such as the OrthADAPT membrane) into the site of the supraspinatus tendon tear. The therapy is designed to enhance the biological healing of the tendon-to-bone interface, leveraging the regenerative and immunomodulatory potential of MSCs to improve functional outcomes and reduce the high rates of re-rupture typically seen with conventional surgical repair techniques.
- Other names
- autologous bone marrow mesenchymal stem cellsMSCs-Hospital San Carlosautologous MSCs
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