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autologous bone marrow-derived mesenchymal stem cells (VA Office of Research & Development)

Development stage: Unknown
Lead developer: VA Office of Research & Development
Modality: Stem Cell Therapies → Cell Therapies
Administration: Intravenous, Intra-arterial, Intramyocardial, Intracoronary, Trans-endocardial, Intrathecal

Overview

An investigational autologous cellular therapy consisting of mesenchymal stem cells (MSCs) harvested from a patient's own bone marrow and expanded for therapeutic use. Developed by the VA Office of Research and Development, this therapy is being evaluated in a Phase 1 pilot crossover study (NCT05925036) for the treatment of pain associated with chronic pancreatitis, specifically in Veterans. The MSCs are intended to exert anti-inflammatory and immunomodulatory effects by secreting bioactive molecules that reduce pancreatic inflammation and fibrosis, potentially aiding in tissue repair and pain reduction.

Other names: mesenchymal stem cellsMSCsautologous bone marrow-derived MSCs

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