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autologous bone marrow-derived mesenchymal stem cells + platelet-rich plasma (Royan Institute)
- Development stage
- Unknown
- Lead developer
- Royan Institute for Stem Cell Biology and Technology
- Modality
- Cell Therapies
- Administration
- Local Injection
01
Overview
This therapeutic intervention, developed by the Royan Institute, involves the autologous transplantation of bone marrow-derived mesenchymal stem cells (MSCs) in combination with platelet-rich plasma (PRP). It is specifically investigated for use during distraction osteogenesis in patients with limb-length discrepancy. The treatment aims to accelerate bone regeneration and mineralization within the distraction callus, thereby shortening the consolidation phase and the overall duration of external fixation. MSCs provide a population of osteogenic progenitor cells capable of differentiating into bone-forming cells, while the PRP serves as a bioactive scaffold and a concentrated source of growth factors—such as transforming growth factor-beta (TGF-β), platelet-derived growth factor (PDGF), and vascular endothelial growth factor (VEGF)—which stimulate cell proliferation, chemotaxis, and angiogenesis.
- Other names
- autologous MSCs + PRPcell and PRP injectionbone marrow derived mesenchymal stem cells + platelet-rich plasma
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