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autologous bone marrow-derived mesenchymal stromal cells (Mario Negri Institute)
- Development stage
- Unknown
- Lead developer
- Mario Negri Institute for Pharmacological Research
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous
01
Overview
Developed by the Mario Negri Institute for Pharmacological Research, this autologous bone marrow-derived mesenchymal stromal cell (MSC) therapy is an investigational immunomodulatory treatment for kidney transplant recipients. The therapy involves the ex vivo expansion of a patient's own bone marrow MSCs, which are then intravenously infused—ideally one day prior to transplantation. The mechanism of action centers on dampening effector T-cell responses and promoting the expansion of FoxP3+ regulatory T cells (Tregs), thereby creating a pro-tolerogenic environment. This approach aims to facilitate the minimization or complete withdrawal of maintenance immunosuppressive therapy while preserving long-term allograft function and preventing chronic rejection.
- Other names
- autologous mesenchymal stromal cellssyngeneic mesenchymal stem cellsMario Negri MSCs
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