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autologous bone marrow-derived mesenchymal stromal cells (Royan Institute, 4c8148)
- Development stage
- Unknown
- Lead developer
- Royan Institute for Stem Cell Biology and Technology
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Implant, Intraarticular
01
Overview
**Autologous bone marrow-derived mesenchymal stromal cells** are a patient-specific stem cell therapy developed by Royan Institute for surgical repair of full-thickness articular cartilage defects of the knee in patients with knee osteoarthritis. In the registered Phase 1 study, the cells were transplanted in combination with a collagen type I scaffold placed at the cartilage-defect site. The intended therapeutic activity is regenerative: mesenchymal stromal cells may support cartilage repair through chondrogenic differentiation potential and local paracrine trophic and immunomodulatory signaling. This was an investigational cell-based product rather than a named, standardized commercial drug product.
- Other names
- autologous bone marrow mesenchymal stem cellsautologous bone marrow-derived mesenchymal stem cellsautologous bone marrow-derived MSCs
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