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autologous bone marrow-derived mesenchymal stromal cells (Universiti Kebangsaan Malaysia)
- Development stage
- Unknown
- Lead developer
- Cytopeutics
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intraarticular
01
Overview
Autologous bone marrow-derived mesenchymal stromal cells are an investigational, patient-specific **stem cell therapy** developed by National University of Malaysia for mild-to-moderate knee osteoarthritis. Bone marrow is harvested from the individual patient, and the mesenchymal stromal cell population is expanded before intra-articular administration. The intended therapeutic activity is regenerative and disease-modifying rather than solely symptomatic: the cells may support cartilage repair through chondrogenic differentiation potential and paracrine trophic, anti-inflammatory, and immunomodulatory effects within the osteoarthritic joint. This exact National University of Malaysia program was evaluated in the randomized, open-label Phase 2 trial NCT01459640.
- Other names
- autologous bone marrow-derived mesenchymal stem cellsautologous BM-MSCsautologous bone marrow-derived MSCs
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