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autologous bone marrow stem cells + tricalcium phosphate + demineralized bone matrix
- Development stage
- Unknown
- Lead developer
- Medtronic
- Modality
- Cell Therapies
- Administration
- Implant
01
Overview
This therapeutic combination is a composite bone graft substitute that utilizes the 'diamond concept' of bone healing by integrating osteogenic, osteoconductive, and osteoinductive elements. It consists of **autologous bone marrow stem cells (BMSCs)**, which provide the cellular machinery (osteogenesis) for new bone formation; **tricalcium phosphate (TCP)**, a synthetic ceramic that serves as a porous, resorbable scaffold (osteoconduction) for cell attachment and mineral deposition; and **demineralized bone matrix (DBM)**, an allograft-derived matrix that provides essential growth factors, primarily bone morphogenetic proteins (BMPs), to trigger the differentiation of progenitor cells into bone-forming osteoblasts (osteoinduction). This combination is frequently employed in complex orthopedic procedures, including the treatment of non-unions, large bone defects, and spinal fusions, where a single-component graft may be insufficient.
- Other names
- BMSC + TCP + DBMcomposite bone graftbone marrow aspirate concentrate + tricalcium phosphate + demineralized bone matrix
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