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autologous dendritic cell + autologous tumor cell antigens vaccine
- Development stage
- Unknown
- Lead developer
- Aivita Biomedical
- Modality
- Dendritic Cell Vaccines → Immune Effector Cells → Other Cell Types → Cell Therapies, Vaccines & Immunotherapeutics
- Administration
- Subcutaneous
01
Overview
Autologous dendritic cell + autologous tumor cell antigens vaccine (DC-ATA) is a personalized, cell-based cancer immunotherapy developed by AIVITA Biomedical. The vaccine is produced by isolating a patient's own dendritic cells and loading them ex vivo with antigens derived from the patient's own tumor-initiating (stem-like) cells, which are expanded in culture. The resulting product is suspended in granulocyte-macrophage colony-stimulating factor (GM-CSF) and administered via subcutaneous injection. This approach is designed to prime the patient's immune system, specifically T lymphocytes, to recognize and eliminate cancer stem cells that are typically resistant to standard chemotherapy and radiation. The platform has been investigated in clinical trials for various solid tumors, including glioblastoma (AV-GBM-1), metastatic melanoma (AV-MEL-1), ovarian cancer (AV-OV-2), and hepatocellular carcinoma (AV-HCC-1).
- Other names
- autologous dendritic cell/autologous tumor cell antigensROOTS
02
Targets
CD28 (Cluster of Differentiation 28)CD40 (Cluster of differentiation 40 receptor)
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